Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia

Article Abstract:

Giving antibiotics to patients with indigestion and Helicobacter pylori infection may eliminate the infection but not reduce their symptoms. This bacterium has been linked to peptic ulcer as well as indigestion. Researchers randomly assigned 328 patients with indigestion and Helicobacter pylori infection to take anti-ulcer medication and antibiotics or anti-ulcer medication alone. The infection was eradicated in 79% of those taking both drugs, compared to 2% of those taking anti-ulcer medication alone. However, symptom reduction occurred in only 27% of those taking both drugs and 21% of those taking anti-ulcer medication alone.

Evaluation, Antibiotics

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Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia

Article Abstract:

Eradicating Helicobacter pylori does not appear to cure dyspepsia. Dyspepsia is the medical term for heartburn. It can sometimes be caused by an ulcer. Helicobacter pylori is a bacterium that has been linked to ulcer formation. Researchers randomly assigned 170 patients with Helicobacter pylori infection and dyspepsia not caused by an ulcer to receive treatment for the infection or a placebo for 14 days. The bacterium was eradicated in 90% of the patients who received the treatment compared to 2% of the placebo group. However, both groups continued to have symptoms of dyspepsia.

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Symptomatic benefit from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia

Article Abstract:

Giving patients with indigestion antibiotics to eradicate Helicobacter pylori infection may reduce their symptoms. This bacterium has been linked to peptic ulcer as well as indigestion. Researchers randomly assigned 318 patients with indigestion and Helicobacter pylori infection but no ulcer to take anti-ulcer medication and antibiotics or anti-ulcer medication alone. The infection was eradicated in 88% of the patients taking both drugs compared to 5% of those taking anti-ulcer medication alone. More patients who took both drugs experienced a decline in symptoms.

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