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Latent Mycobacterium tuberculosis - persistence, patience, and winning by waiting

Article Abstract:

Highlights of ongoing research into Mycobacterium tuberculosis infection mechanisms are presented. Topics include the inaccuracy inherent in animal models of latency, improvements in the in vitro model of latency, identification of late-stage survival genes, and exogenous re-infection patterns.

Author: Bishai, William R., Manabe, Yukari C.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Anti-infective agents, Mycobacterium tuberculosis

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A post-genomic perspective

Article Abstract:

This article examines innovations in genetic research, focusing on how the knowledge of the Mycobacterium tuberculosis genome sequence can improve scientists' understanding of complex biology of infections. The relationship between M. tuberculosis and the human immune system is discussed.

Author: Young, Douglas B.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Analysis, Innovations, Tuberculosis, Genomes, Genetic research

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Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity

Article Abstract:

Research on a vaccine from recombinant Saccharomyces cerevisiae yeast examines its impact on the immune response of CD8+ cytotoxic T lymphocytes to tumor and viral antigens. Topics include cellular immunity, the production of antigens by dendritic cells, and histocompatibility.

Author: Kuritzkes, Daniel R., Stubbs, Andrew C., Martin, Kathleen S., Coeshott, Claire, Skaates, Serena V., Bellgrau, Donald, Franzusoff, Alex, Duke, RIchard C., Wilson, Cara C.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Statistical Data Included, Antigen presenting cells, Lymphocytes, Cellular immunity, Histocompatibility

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Subjects list: Research, United States, Genetic aspects, Vaccines, Mycobacterial infections, Mycobacterium infections
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