Local gene knockdown in the brain using viral-mediated RNA interference

Article Abstract:

The use of viral-mediated RNA interference (RNAi) to generate a specific knockdown of Th, the gene encoding for tyrosine hydroxylase, within midbrain neurons of adult mice, is elaborated. The results emphasize the utility of viral-mediated RNAi for rapid production and testing of new genetic disease models.

RNA interference

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Astrocytes get in the act in epilepsy

Article Abstract:

The release of glutamate and other amino acids from a single astrocyte are induced by experimentally elevating intracellular calcium levels. The elevations in amino acids are associated with paroxysmal depolarization shift (PDS)-like epileptiform responses of neighboring neurons.

United States, Glutamate, Astrocytes

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Seizing hold of seizures

Article Abstract:

A major step forward in efforts to develop new therapies for epilepsy, by showing that genetic manipulation of small regions of the brain can alter seizure susceptibility and provide neuro protection are presented.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Neurological R&D, Care and treatment, Neurological research

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