Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling
Article Abstract:
Cord blood transplants may be safer than bone marrow transplants. Cord blood is blood taken from the umbilical cord of a newborn baby. It contains immature blood cells that are less likely to cause adverse reactions. One such reaction is graft-versus-host disease (GVHD), which often occurs in people who receive a bone marrow transplant. A study of 113 children who received a cord blood transplant and 2,052 who received a bone marrow transplant found that the risk of developing GVHD was 60% lower in those who received a cord blood transplant.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
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Changing trends in allogeneic bone marrow transplantation for leukemia in the 1980s
Article Abstract:
Use of bone marrow transplantation to treat leukemia patients in the 1980s has moderately improved survival and decreased the probability of a relapse. Leukemia patients who receive a bone marrow transplant usually receive tissue donated by a sister, brother or other relative with similar immunological characteristics. Among leukemia patients transplanted with bone marrow donated by a sibling between 1980 and 1989, the probability of death from complications decreased from an average of 28% to an average of 22% between 1980 and 1989. The probability of a relapse decreased from an average 46% to an average of 38% between 1980 and 1989 for patients with intermediate leukemia, but not for those with early or advanced leukemia. These improvements can be attributed to better transplantation practices, rather than to better patient selection.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1992
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Long-term follow-up of adults with acute lymphoblastic leukemia in first remission treated with chemotherapy or bone marrow transplantation
Article Abstract:
Survival rates seem to be similar for leukemia patients treated with chemotherapy and those receiving bone marrow transplants. However, deaths associated with treatment and probability of relapse may differ between these two methods of treating leukemia. Researchers followed 484 patients with leukemia treated with chemotherapy and 234 patients with leukemia who received a bone marrow transplant from a matched brother or sister. After nine years, the likelihood of survival was 32% for the patients treated with chemotherapy and 34% for the patients who received bone marrow transplants. The likelihood of death associated with the treatment after nine years was 5% for chemotherapy and 53% for bone marrow transplantation. The probability of the leukemia returning after nine years was 66% for patients receiving chemotherapy and 30% for those receiving a bone marrow transplant.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1995
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