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Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

Article Abstract:

The current standard of care for newly diagnosed glioblastoma, the most common primary brain tumor in adults, is surgical resection to the extent feasible, followed by adjuvant radiotherapy. Radiotherapy alone was compared with radiotherapy plus temozolomide, given concomitantly with and after radiotherapy in terms of efficacy and safety.

Author: Bogdahn, Ulrich, Stupp, Roger, Brandes, Alba A., Belanger, Karl, Taphoorn, Martin J. B., Fischer, Barbara, Weller, Michael, Bent, Martin J. van den, Mason, Warren P., Marosi, Christine, Lacombe, Denis, Allgeier, Anouk, Gorlia, Thierry, Ludwin, Samuel K., Janzer, Robert C., Curschmann, Jurgen, Cairncross, J. Gregory, Mirimanoff, Rene O., Eisenhauer, Elizabeth
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
United Kingdom, Health aspects, Usage, Diagnosis, Radiotherapy, Glioblastoma multiforme, Temozolomide

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Breast cancer-loss of PTEN predicts resistance to treatment

Article Abstract:

PTEN, the lipid phosphatase and tensin homologue, is a key tumor suppressor. A recent study by Nagata and colleagues shows that PTEN not only antagonizes tumorigenesis but also senditizes breast cancers.

Author: Pandolfi, Pier Paolo
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Medical Research, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Care and treatment, Breast cancer, Tumor antigens, Medicine, Experimental, Tumour antigens

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Subjects list: Research
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