Decreased expression of the memory marker CD26 on both CD4+ and CD8+ T lymphocytes of HIV-infected subjects

Article Abstract:

HIV infection may decrease the number of CD4+ and CD8+ T cells with the CD26 memory marker on their surface. Decreased production of memory markers may impair immunological memory in HIV-infected individuals. Researchers compared number and proportion of CD4+ and CD8+ T cells with the CD26 memory marker in 72 HIV-positive individuals and 42 healthy individuals (control group). HIV-infected individuals had a significantly lower absolute number and proportion of CD4+ and CD8+ T cells with the CD26 memory marker than individuals in the control group. The absolute number of CD4+ T cells with the CD26 memory marker decreased with progressive stages of HIV infection. The absolute number of CD8+ T cells with the CD26 memory marker was low at all stages of infection.

HIV infection, HIV infections, CD4 lymphocytes, CD8 lymphocytes

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Immunopathogenesis of HIV infection

Article Abstract:

Concentrations of the human immunodeficiency virus (HIV) found in the lymph system suggest that the lymph nodes are an important site for viral reproduction. HIV is the virus that causes AIDS. The lymph system plays an important role in fighting infections in the body. The lymph nodes trap the virus as a first step toward fighting it. This may be why there seems to be a latency period after people have been exposed to HIV but before it is detectable by blood tests. CD4 T-cells, which help fight infection, travel to the lymph node where they become activated and exposed to the virus. HIV causes a reduction in the number of T-cells in a variety of ways. High levels of HIV are found in the lymph nodes at all stages of HIV infection.

AIDS (Disease), Lymphatics, Lymphatic system

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