Maternal second trimester serum tumor necrosis factor-alpha-soluble receptor p55 (sTNFp55) and subsequent risk of preeclampsia

Article Abstract:

Concentrations of prediagnostic s TNFp55, a soluble receptor for tumor necrosis factor-alpha (TNF-alpha), have been measured in 35 women with preeclampsia and 222 women who were normotensive to find out whether sTNFp55 elevations precede clinical preeclampsia manifestation. Mean second trimester serum sTNFp55 concentrations were 14.4% higher in preeclamptic women than in normotensive controls. Levels were measured by enzyme-linked immunosorbent assay. Relative risk of preeclampsia was higher across successively higher quintiles of sTNFp55. Adjusting for maternal age, parity and body fat, the relative risk between extreme quintiles was 3.3. It appears that the level of TNF-alpha in maternal circulation is higher before the clinical manifestation of the disorder. Findings are consistent with the role cytokines are thought to have in affecting endothelial dysfunction and pathogenesis of preeclampsia. It may be that lowering TNF-alpha concentrations during pregnancy can change the incidence and/or degree of preeclampsia.

Risk factors, Physiological aspects, Proteins, Pregnancy, Cell receptors, Tumor necrosis factor, Vascular endothelium

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Performance of a group B streptococcal prophylaxis protocol combining high-risk treatment and low-risk screening

Article Abstract:

Researchers describe an effective screening policy to prevent the transmission of group B streptococcal from a pregnant woman to her baby during delivery. All women at high risk are given antibiotics and all women at low risk are given a rapid blood test. Only those who test positive for the bacteria are treated.

Care and treatment, Evaluation, Streptococcal infections, Prevention, Medical screening, Health screening

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Weight at birth and subsequent risk of preeclampsia as an adult

Article Abstract:

Research has been conducted on the role of maternal weight in preeclampsia development which is a precursor to adult chronic disease. Results demonstated that women who are small at birth and become overweight as adults are at risk of developing preeclampsia.

Research and Development in the Physical, Engineering, and Life Sciences, Science & research, Research and Testing Services, Gynecological R&D, Health aspects, Analysis, Causes of, Complications and side effects, Obesity, Birth weight, Obstetrics, Gynecological research, Birth size

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