Maternal serum vitamin A levels are not associated with mother-to-child transmission of HIV-1 in the United States

Article Abstract:

Vitamin A deficiency does not appear to contribute to HIV transmission during pregnancy. Researchers took blood samples during the third trimester from 95 pregnant HIV-infected women and measured the levels of vitamin A and several antioxidants such as vitamin E. The women and their infants were followed until the infant was 6 months old. At 6 months, 16 of the infants tested positive for HIV. However, there was no association between low vitamin A levels and HIV transmission.

HIV infections, Disease transmission, Pregnancy, HIV infection in pregnancy, Vitamin A deficiency

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Molecular cloning of full-length HIV-1 genomes directly from plasma viral RNA

Article Abstract:

Researchers have successfully synthesized the full-length HIV-1 genome from blood samples of HIV-infected patients. This was done by using reverse transcriptase to convert viral RNA to DNA and then using the polymerase chain reaction to amplify the DNA. Hundreds of viral genomes resulted, some from patients with low levels of virus. Most sequence databases contain viral sequences developed from the proviral DNA associated with infected cells.

Methods, HIV (Viruses), HIV, Cloning

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CCR5 genotype and resistance to vertical transmission of HIV-1

Article Abstract:

A mutation in the CCR5 gene appears to protect newborn babies of HIV-infected mothers from contracting the virus. CCR5 is a cell receptor that HIV uses to enter cells. Blocking the CCR5 receptor could prevent HIV transmission from mother to baby.

Prevention, Gene mutations, Gene mutation, HIV infection in children, Pediatric HIV infections, Cell receptors

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