Methylnaltrexone for Reversal of Constipation Due to Chronic Methadone Use: A Randomized Controlled Trial

Article Abstract:

Low-dose methylnaltrexone can relieve constipation in patients taking opioids for pain. Constipation is the most common adverse effect of opioid pain medications. Researchers randomly assigned 22 people with opioid-induced constipation to receive a 9-minute intravenous dose of methylnaltrexone or placebo. Compared to those who received placebo, all 11 patients who received methylnaltrexone were able to have a bowel movement and food traveled from their mouth to their colon in about half the time.

Drug therapy, Constipation, Naltrexone, Opioids

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Fetal loss associated with excess thyroid hormone exposure

Article Abstract:

The effects of thyroid hormone(TH) excess on fetuses carried by mothers with resistance to TH, who are euthyroid are studied. The result reveals that the lower birth weight and suppressed levels of TSH in unaffected infants born to affected mothers indicates that the high maternal TH levels produce fetal thyrotoxicosis.

Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Thyroid & Antithyroid Prep, Fetus, Influence, Thyroid hormones

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Herbal Medicines and Perioperative Care

Article Abstract:

Some medicinal plants can cause problems in patients who are having surgery. Garlic, ginkgo, and ginseng can cause bleeding, ephedra can affect the heart, ginseng can cause low blood sugar, and kava, valerian and St. John's wort can interact with anesthetics and other drugs used during the postoperative period.

Analysis, Medicinal plants, Medicine, Herbal, Herbal medicine, Herb-drug interactions, Drug-herb interactions

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