Missence variations in the fibulin 5 gene and age-related macular degeneration

Article Abstract:

Age-related macular degeneration (AMD), the most common cause of irreversible vision loss, is studied and the implication of fibulin genes in the pathogenesis is identified. Missence mutations in the fibulin 5 gene were found in 1.7 percent patients of the 402 patients tested who suffered from AMD.

Gene mutations, Gene mutation

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Complement C3 variant and the risk of age-related macular degeneration

Article Abstract:

Single-nucleotide polymorphisms (SNPs) spanning the complement genes C3 and C5 are genotyped in subjects with age-related macular degeneration and in control subjects. The results have shown that complement C3 is vital on the pathogenesis of age-related macular degeneration.

Single nucleotide polymorphisms

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Age-related macular degeneration and the extracellular matrix

Article Abstract:

Abnormalities of the extracellular matrix of the eye cause irreversible blindness in elderly persons in the West. Mutations in the Fibulin 5 genes are the main cause of these problems in the elderly.

Health aspects, Aged, Elderly, Genetic research

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