Multicenter comparison of clotrimazole vaginal tablets, oral metronidazole, and vaginal suppositories containing sulfanilamide, aminacrine hydrochloride, and allantoin in the treatment of symptomatic Trichomoniasis

Article Abstract:

Treatment with metronidazole tablets appears to be more effective than either medicated vaginal tablets or suppositories among patients with trichomoniasis. One hundred sixty-eight women with active trichomoniasis were treated with either oral metronidazole tablets clotrimazole vaginal tablets, or vaginal suppositories containing allantoin, sulfanilamide, and aminacrine. Vaginal secretion sample testing confirmed successful treatment among 80% of the patients treated with metronidazole, 18.6% of the patients treated with suppositories, and 11% of those treated with vaginal tablets. All patients reported an improved vaginal condition.

Clotrimazole

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Trichomoniasis in a postmenopausal women cured after discontinuation of estrogen replacement therapy

Article Abstract:

Discontinuing hormone replacement therapy may prove effective in postmenopausal women infected with Trichomonas (T.) vaginalis who are unresponsive or allergic to metronidazole. Increased estrogen levels may increase the risk for developing T. vaginalis infections. A 55-year-old woman taking estrogen therapy developed a T. vaginalis infection, was treated with metronidazole, and later developed an allergic reaction to the treatment. Vaginal examinations and laboratory tests showed no evidence of the infection after she stopped taking the estrogen therapy.

Health aspects, Care and treatment, Diseases, Hormone therapy, Postmenopausal women, Estrogen, Estrogens

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A pilot study of metronidazole vaginal gel versus oral metronidazole for the treatment of Trichomonas vaginalis vaginitis

Article Abstract:

A vaginal gel containing metronidazole appears to be less effective than oral metronidazole in treating vaginal infections with Trichomonas vaginalis. This organism is the cause of trichomoniasis, which affects 3 million American women each year. Researchers randomly assigned 15 women to take oral metronidazole and 15 women to use a metronidazole vaginal gel. All the women taking oral metronidazole were cured, compared to 44% of the women using the gel. The gel could still be useful in patients who cannot take oral metronidazole.

Vagina, Medication by, Vaginal medication, Bacterial vaginitis

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