Mutations in mitochondrial transfer ribonucleic acid genes in preeclampsia

Article Abstract:

Preeclampsia may be an inherited condition, and may be caused by genetic mutations of DNA mitochondria. Preeclampsia is a serious complication of pregnancy involving high blood pressure and protein in the urine. Researchers sequenced mitochondrial transfer ribonucleic acid (RNA) genes in 11 women from two families having a high incidence of preeclampsia with or without seizures. Two different mutations were found in transfer RNA leucine molecules of mitochondrial DNA. Each family had a different mutation pattern. Leucine is a major amino acid encoded by mitochondrial DNA, and a decrease in its function could damage protein synthesis. This in turn could damage placental function. Mitochondrial dysfunction was not observed in blood samples from the same women when they were not pregnant.

Abnormalities, Mitochondrial DNA

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Angiotensinogen and endothelial nitric oxide synthase gene polymorphisms among Hispanic patients with preeclampsia

Article Abstract:

A polymorphism of the gene for endothelial nitric oxide synthase (NOS3*A) appears to be linked to preeclampsia in Hispanic women. Preeclampsia is a serious complication of pregnancy. However, there is no association between preeclampsia and the AGT*T form of the gene for angiotensinogen.

Genetic polymorphisms

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Identification of monozygotic twins that are concordant for preeclampsia

Article Abstract:

A serious complication of pregnancy called preeclampsia may have a genetic basis. Researchers identified two sets of identical female twins in which both women had preeclampsia during pregnancy. In a set of triplets, two had preeclampsia during pregnancy and one did not.

Case studies, Familial diseases, Twins

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