Nitric oxide-eluting polyurethanes-vascular grafts of the future?

Article Abstract:

A nitric donor is incorporated into a polyurethane to assess its interactions with platelets, vascular smooth-muscle cells, and endothelial cells, all of which are critical to graft occlusion. It is found that the mechanical properties of the synthesized polymer is similar to those of commercial polyurethane vascular grafts and that nitric oxide is released in two phases, a rapid burst during the first 48 hours, followed by a slower, sustained release over a two-month period.

Science & research, Plastics Material and Resin Manufacturing, Industrial Gas Manufacturing, Plastics materials and resins, Industrial gases, Nitric Oxide, Urethane Resins, Urethane Resins ex Elastomer & Foam, Research, Polymers, Polyurethanes

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RNA interference as potential therapy -- not so fast

Article Abstract:

RNA interference (RNAi) is successfully used to treat several animal models of human disease, providing a possible therapeutic potential to the approach. However, a study indicates that the method interferes with an innate mechanism of gene silencing and is associated with toxic effects and death in animals, thus necessitating a comprehensive understanding of the endogenous molecular mechanisms involved to design safe and effective RNA-based gene therapies.

Health aspects, Care and treatment, Analysis, Usage, Diseases, Gene therapy, Gene silencing, RNA interference

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Predicting outcomes after renal transplantation -- new tools and old tools

Article Abstract:

Two studies published in 2003 provide methods for determining whether a transplanted kidney will fail prematurely and be rejected. One involves using ultrasound to measure the resistance to blood flow in the arteries that supply blood to the kidneys. The other is DNA microarray technology, which can measure the expression of hundreds of genes in a single biopsy sample.

Editorial, Diagnosis, Graft rejection, Kidney transplantation

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