No difference in GBV-C/HGV viremia in donors with normal or elevated ALT

Article Abstract:

Researchers at the Malmo University Hospital of Lund University in Sweden identified the proliferation of GB virus C (GBV-C) and hepatitis G virus (HGV) among blood donors in Sweden. The finding generated concern over probable injuries that blood recipients may get from GBV-C and HGV since alanine aminotransferase levels cannot accurately determine the presence of GBV-C and HGV in the blood. Polymerase chain reaction is the only available screening test for the viruses. The researchers emphasized the need for general blood donor screening in Sweden.

Sweden, Social policy, Disease transmission, Blood, Blood transfusion, Hepatitis viruses, Blood chemical analysis

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Recombinant viruses elicit immune responses in mice

Article Abstract:

An experiment has revealed that infected mosquito bites could enhance the protective effect of malaria vaccines. This was shown when mice were immunized with a cytotoxic T lymphocyte epitope of the circumsporozoite protein of Plasmodium falciparum and P falciparum sporozoites. The experiment was based on previous studies which showed that re viruses which express sequences of foreign antigens can elicit antibody and cellular responses against these sequences.

Health aspects, Care and treatment, Research, Mice, Mice (Rodents), Immunity, Immunity (Physiology), Malaria, Bites and stings, Bites (Injuries), Stings (Injuries), Parasite vaccines

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Recombinant OspC used in an ELISA enables early diagnosis

Article Abstract:

Lyme disease can be diagnosed in its early stage by an enzyme-linked immunosorbent assay (ELISA) that uses recombinant outer surface protein C (OspC) or the flagellin of Borrelia burgdorferi or both. When the ELISA combination was compared to a commercial immunoglobulin M (IgM) ELISA that uses a cell extraction from Borrelia afzelii, the recombinant OspC-14-kDA antigen IgM ELISA has been found out to be as sensitive as a whole-cell extract ELISA.

Diagnosis, Lyme disease, Enzyme-linked immunosorbent assay, Recombinant proteins

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