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Noninvasive diagnosis of renal-allograft rejection by measurement of messenger RNA for perforin and granzyme B in urine

Article Abstract:

Measuring the amount of perforin and granzyme B in cells in urine samples may detect organ transplant recipients whose transplanted organ is being rejected by the patient's immune system. These two proteins are produced by T cells that destroy other cells.

Author: Sharma, Vijay K., Li, Baogui, Hartono, Choli, Ding, Ruchuang, Ramaswamy, Ravi, Qian, Biao, Serur, David, Mouradian, Janet, Schwartz, Joseph E., Suthanthiran, Manikkam
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
Analysis, Diagnosis, Urine, Urinalysis

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Messenger RNA for FOXP3 in the urine of renal-allograft recipients

Article Abstract:

Levels of messenger RNA for FOXP3, a specification and functional factor for regulatory T lymphocytes, and mRNA for CD25, CD3E, perforin, and 18S ribosomal RNA are measured with a kinetic, quantitative polymerase-chain-reaction assay. Results reveal that measurement of FOXP3 mRNA in urine might offer a noninvasive means of improving the prediction of outcome of acute rejection of renal transplants.

Author: Sharma, Vijay K., Hartono, Choli, Ding, Ruchuang, Schwartz, Joseph E., Muthukumar, Thangamani, Seshan, Surya V., Kapur, Sandip, Dadhania, Darshana, Hancock, Wayne W., Baogui Li, Snopkowski, Catherine, Suthantiran, Manikkam, Naqvi, Rubina, Lee, Jun B.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
Science & research, Research, Chronic kidney failure

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HLA-mismatched renal transplantation without maintenance immunosuppression

Article Abstract:

A new approach for bone marrow and kidney transplant of a patient with renal disease with a HLA-mismatched living related donor is discussed. The transplantation is found to be extremely effective, as it leads to the discontinuation of the immunosuppressive therapy.

Author: Sachs, David H., Shaffer, Juanita, Sykes, Megan, Preffer, Frederic I., Ding, Ruchuang, Suthanthiran, Manikkam, Spitzer, Thomas R., Colvin, Robert B., Fishman, Jay A., Williams, Winfred W., Jr., Goes, Nelson B., Sharma, Vijay, Kawai, Tatsuo, Cosimi, Benedict, Wong Waichi, Tolkoff-Rubin, Nina, Saidman, Susan L., Dey, Bimalangshu, Ko, Dicken S.C., Hertl, Martin
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2008
Complications and side effects, Drug therapy, Genetic aspects, Dosage and administration, Immunosuppressive agents, Kidney diseases, Clinical report

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Subjects list: Graft rejection, Kidneys, Kidney transplantation, Care and treatment, United States
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