Novel therapies dominate American Cancer Society's 35th Annual Science Writers Seminar

Article Abstract:

Innovations in therapy were discussed at the 35th Annual American Cancer Society's Science Writers Seminar. A drug currently being tested may inhibit cancer migration by blocking calcium-dependent signaling pathways. Abnormalities in signal transduction are thought to promote malignancy, cancer growth and metastasis. In another study, researchers are implanting foreign tissues into brain tumors to initiate an immune system attack on the tumor. A vaccine for melanoma was tested on 136 patients with advanced metastatic melanoma. In the study, patients who received the vaccine had significantly greater short term and long term survival rates than patients who did not receive the vaccine. In a study on the genetic aspects of melanoma, researchers have identified markers on chromosome 9 that are associated with an increased risk of melanoma. Other researchers are working on a tablet form of anti-cancer antibodies for people with an increased risk of inheriting cancer.

Care and treatment, Conferences, meetings and seminars, Cancer treatment, Chemotherapy, American Cancer Society

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Scientists 'build a better mouse' to trap biochemical secrets of radiation-resistant cancer cells

Article Abstract:

Scientists have used genetic engineering techniques to develop a mouse that may be more resistant to lethal doses of ionizing radiation. This mouse has multiple copies of the raf oncogene, or a gene that causes cancer, that may cause radiation resistance. Some types of cancer cells are resistant to treatment with ionizing radiation, while others are not. Individuals from families with Li-Fraumeni syndrome are genetically predisposed to developing cancer at an early age. An oncogene that causes radiation-resistance has been found in members of one family with Li-Fraumeni syndrome. The raf oncogene is from the connective tissue cells of one of these family members. When this gene is transplanted into mice, it changes normal cells into cancer cells, and makes them resistant to high levels of radiation. Mice with the raf oncogene can be used to study the treatment of radiation-resistant cancer.

Models, Genetically modified mice

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CT scans probe secrets of Italian masters' violins

Article Abstract:

Musicians are finding that a CT scan can reveal much about the condition of a violin. One group of radiologists have scanned over 30 instruments, including 14 considered to be masterpieces. The scan can detect defects invisible to the naked eye, which can determine their value. Warping and evidence of repair can also be detected. The scan can identify forgeries and stolen instruments, and prevent insurance fraud. The radiologists hope to scan more than 400 instruments in the collection of the Smithsonian Institution.

Usage, Portrayals, CT imaging, CAT scans, Violin, Violins

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