AgNOR area in interphase nuclei of human tumours correlates with the proliferative activity evaluated by bromodeoxyuridine labelling and Ki-67 immunostaining

Article Abstract:

The nucleolar organizer regions (NORs) are structures formed by certain genes in cells that are dividing. The NORs can be stained with silver (Ag) for detection under the microscope. They are then known as AgNORs. Large numbers of AgNORs are found in malignant (invasive) cancer cells compared with benign cancer cells. The levels of AgNORs were examined in 27 human cancers originating from various sites in the body, including the thyroid, breast, lung, liver, and colon. The results were compared with those from two other laboratory tests which determine if the cells are dividing. These tests are known as the Ki-67 immunostaining index and the incorporation of bromodeoxyuridine (BrdU) into cells. The results obtained by the three tests were similar in all the types of tumors examined. This indicates that AgNORs can be used as a laboratory test to determine the extent of proliferation of cells. The use of AGNORs is advantageous because it can be used without special preparation of tissues other than that which is routinely done for microscopic examination of tissues. (Consumer Summary produced by Reliance Medical Information, Inc.)

Diagnosis, Cancer, Cancer diagnosis, Nucleolus organizer region

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Gastrointestinal stromal tumours: Correlation of immunophenotype with clinicopathological features

Article Abstract:

Tumors of the stroma (supportive tissues) of the gastrointestinal (GI) tract can contain different types of tissue. Previous studies have shown that the appearance of the tumor tissue is not always predictive of its biological behavior, which often makes prognosis difficult. Sixty cases of GI stromal tumors were examined using tests to detect nervous or muscle cellular components. Thirty-six percent of the tumors contained neural tissue; 31 percent contained smooth muscle; 20 percent contained both neural and muscular tissue; and 13 percent did not contain either of the tissue types. Forty-two of the cases were followed for approximately five years and the prognosis of disease was correlated with the type of tissue the tumor contained. Tumors of the stomach that only contained muscle tissue and were not rapidly dividing were benign. In individuals with malignant tumors, those with tumors containing only neural tissue had the best prognosis. Larger studies are recommended to elaborate on these findings. (Consumer Summary produced by Reliance Medical Information, Inc.)

Case studies, Physiological aspects, Identification and classification, Histology, Pathological, Pathological histology, Gastrointestinal cancer, Digestive system cancer

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