Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency

Article Abstract:

A mutation in the gene for the norepinephrine transporter may cause orthostatic intolerance. People with orthostatic intolerance experience lightheadedness, fatigue, fainting and altered mental status when they stand upright. In a study of a woman with orthostatic intolerance, researchers found that she had a mutation in the gene for the norepinephrine transporter. This is a protein that removes norepinephrine once it has been released from nerve endings. The mutation caused almost complete loss of function in this transporter, which would cause norepinephrine levels to increase. This in turn would cause excessive activation of the sympathetic nervous system.

Gene mutations, Gene mutation, Genetic aspects, Fainting, Noradrenaline, Norepinephrine

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Sudden death from cardiac arrest -- improving the odds

Article Abstract:

The American Heart Association and the National Heart, Lung, and Blood Institute will support a large clinical trial to determine whether non-medical personnel can learn to use automated external defibrillators. These devices can restore heart rhythm in people in cardiac arrest and are so simple to use that sixth-grade children were able to use them effectively.

Care and treatment, Editorial, Innovations, Community health services, Defibrillators, Cardiac arrest

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The neuropathic postural tachycardia syndrome

Article Abstract:

Postural tachycardia syndrome may be caused by an abnormal nervous system response in the legs, according to a study of 10 patients and 8 healthy volunteers. People with postural tachycardia syndrome develop a rapid heartbeat when they stand up from a sitting position.

Abnormalities, Causes of, Nervous system, Sympathetic, Sympathetic nervous system

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