Menstrual arthritis

Article Abstract:

Some women suffer from transient polyarthritis that occurs only during menstruation. Polyarthritis is an inflammatory disorder that affects several joints simultaneously. A 30-year-old woman had been suffering from polyarthritis that developed during the first 48 hours of her menstrual period each month for approximately nine months. The arthritic symptoms usually subsided after approximately four to five days. They included pain and tenderness in her wrists, shoulders and knee joints. She also experienced a decreased range of motion in her wrists and shoulders. She did not experience any symptoms between menstrual periods and had no residual damage. Her menstrual cycle was regular with no other abnormalities. She was treated with danazol over a seven-month period, during which time she stopped menstruating completely and suffered no episodes of polyarthritis. She had no symptoms for about 18 months after stopping treatment. When symptoms recurred, she resumed successful treatment with danazol.

Complications and side effects, Menstruation

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IL-1 has no direct role in the IGF-1 non-responsive state during experimentally induced arthritis in mouse knee joints

Article Abstract:

The substance interleukin-1 (IL-1) by itself does not appear to prevent insulin-like growth factor 1 (IGF-1) from responding in experimentally induced arthritis in mice. IL-1 and IGF-1 have opposite effects on cartilage cells in joints, and keep things in balance. IGF-1 is important for keeping cartilage cells intact. IGF-1 non-responsiveness during arthritis may result in the destruction of cartilage. Researchers induced arthritis in the knee joints of female mice, and found that while IL-1 alone does not cause IGF-1 non-responsiveness, it does contribute to it. Various other inhibitors of IGF-1 may be at work during arthritis in addition to IL-1.

Physiological aspects, Interleukin-1, Insulin-like growth factor 1, Insulin-like growth factor I

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