PCR analysis of HIV-seronegative, heterosexual partners of HIV-infected individuals

Article Abstract:

The rate of transmission of HIV from infected people to their regular sex partner appears to be low. Researchers used the polymerase chain reaction (PCR) to detect HIV DNA in 203 HIV antibody-negative partners of an HIV-infected person. Only three were found to be positive by PCR and two samples may have been contaminated. The one woman found to be definitely positive by PCR had unprotected sex with her husband for two years after she discovered he was HIV-positive. Although HIV DNA was found in her blood cells, she was HIV antibody-negative, had normal CD4 T lymphocyte counts, and was in good health. Extensive follow-up will determine whether she will eventually develop AIDS or whether her immune system was able to successfully defeat the virus.

Health aspects, HIV infection, HIV infections, Disease transmission, Heterosexuals

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A vaccinia-gp160-based vaccine but not a gp160 protein vaccine elicits anti-gp160 cytotoxic T lymphocytes in some HIV-1 seronegative vaccinees

Article Abstract:

A vaccine of live recombinant vaccinia-gp160 may trigger the production of cytotoxic T lymphocytes (CTL) that will specifically attack part of the HIV virus. One group of HIV negative volunteers received immunizations of 640 micrograms of gp160-LAI, while another group received immunizations 640 micrograms of recombinant vaccinia-gp160-LAI. Researchers then grew CTL drawn from each subject and tested their ability to specifically attack cells infected with the viral gene for gp160-LAI. Five control subjects and three of the gp160 vaccine recipients did not generate CTL that were specific to gp160. However, six of seven of the recombinant vaccinia-gp160-LAI recipients did produce CTL specific to gp160.

Evaluation

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Factors related to the willingness of young gay men to participate in preventive HIV vaccine trials

Article Abstract:

Most young gay men are willing to participate in clinical trials of HIV vaccines in order to help end the HIV epidemic, despite some concerns about the safety of the vaccines. Researchers surveyed 390 gay men who were HIV-negative or untested, and 91% were willing to receive an experimental HIV vaccine. The willingness was prompted by both altruistic motives and a desire to protect themselves from HIV infection. Fear of HIV transmission, or fear of receiving a placebo vaccine, were reported by those unwilling to participate in vaccine trials.

United States, Beliefs, opinions and attitudes, Gay men

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