Paraneoplastic pemphigus with autoantibody deposition in bronchial epithelium after autologous bone marrow transplantation

Article Abstract:

A patient was admitted to a hospital with painful blisters on his lips, inside his mouth and nose and on his penis; the blisters later spread over his body. He was in remission from non-Hodgkin's lymphoma after having received a bone marrow transplant. A skin biopsy revealed a disruption of the connections between individual skin cells. A special stain of the tissue showed the presence of antibodies bound to the skin cells. Corticosteroid treatment improved the skin lesions, but not the lesions in his mouth and eyes. Plasmapheresis was begun, but he developed complications during treatment. He developed pneumonia, which was treated with antibiotics. His lung disease progressed, and lung biopsy specimens retrieved by bronchoscopy revealed antibodies between cells in the lung. He developed a lung infection with aspergillus and died a week later. An autopsy revealed lesions in the trachea, esophagus and lungs similar to pemphigus, a skin disease characterized by widespread blistering.

Case studies, Paraneoplastic syndromes

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Allergic and immunologic skin disorders

Article Abstract:

The skin provides both physical and immunological protection from the environment. Allergic reactions may produce redness or hives that resolve quickly or with symptomatic treatment. Contact dermatitis from metal in jewelry, poison oak, and cosmetics affects many people. Atopic dermatitis is a common allergic condition, particularly in children, characterized by chronic itching and redness. Mastocytosis describes conditions which produce red-brown lesions and other symptoms caused by excess mast cells in the skin. Pemphigus causes blistering from an immune reaction against the skin.

Analysis, Atopic dermatitis, Urticaria, Hives (Disease), Contact dermatitis, Bullous pemphigoid, Angioneurotic edema

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Research Advances in Pemphigus

Article Abstract:

Pemphigus is an autoimmune disorder that causes severe blistering of skin and mucous membranes. The agent that causes the autoantibodies is not yet known but it appears to be an environmental agent. Once it is discovered, antigen-specific immunotherapy could be used to treat the disease.

Research

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