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Parity, oral contraceptives, and the risk of ovarian cancer among carriers and noncarriers of a BRCA1 or BRCA2 mutation

Article Abstract:

Oral contraceptives will not reduce the risk of ovarian cancer in women with the BRCA1 or BRCA2 gene mutation, according to a study of 840 women with ovarian cancer and 751 healthy volunteers. However, pregnancy does reduce the risk, which decreases with each additional birth. Thirty percent of the ovarian cancer patients had one of the mutations, compared to 1.7% of the healthy volunteers.

Author: Wacholder, Sholom, Ben-Baruch, Gilad, Hartge, Patricia, Chetrit, Angela, Modan, Baruch, Hirsh-Yechezkel, Galit, Lubin, Flora, Beller, Uzi, Fishman, Amiram, Menczer, Joseph, Struewing, Jeffery P., Tucker, Margaret A.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2001
Risk factors, Oral contraceptives

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High frequency of BRCA1 185delAG mutation in ovarian cancer in Israel

Article Abstract:

The presence of the 185delAG mutation in the BRCA1 gene may increase a woman's risk of developing ovarian cancer. The BRCA1 gene has been linked to breast and ovarian cancer. Researchers tested for the gene mutation in 79 women with ovarian cancer, 62 women hospitalized for other reasons and 120 healthy volunteers. Almost 40% of the ovarian cancer patients with a family history had the mutation. Thirteen percent of the ovarian cancer patients with no family history also had the mutation. Only one person among the other two groups had the mutation.

Author: Ben-Baruch, Gilad, Modan, Baruch, Hirsh-Yechezkel, Galit, Lubin, Flora, Beller, Uzi, Fishman, Amiram, Menczer, Joseph, Friedman, Eitan, Gak, Eva, Sade-Bruchim, Revital Bar, Theodor, Livia, Dgani, Ram, Papa, Moshe
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1996

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The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews

Article Abstract:

The risk of cancer in people who have mutations in the BRCA genes may be lower than previously estimated. Researchers analyzed blood samples from 5,318 Ashkenazi Jews for BRCA1 and BRCA2 gene mutations. One hundred twenty people (2%) had a mutation of either gene. The estimated risk of breast cancer in women with a mutation was 33% by the age of 50 and 56% by the age of 70. The risk of ovarian cancer was 16% by the age of 70, as was the risk of prostate cancer in men with a mutation. Previous research has shown that some mutations confer greater risk than others.

Author: Wacholder, Sholom, Hartge, Patricia, Struewing, Jeffery P., Tucker, Margaret A., Brody, Lawrence C., Baker, Sonya M., Berlin, Martha, McAdams, Mary, Timmerman, Michelle M.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
Prostate cancer, Breast cancer, Ashkenazim

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Subjects list: Health aspects, Gene mutations, Gene mutation, Ovarian cancer, Genetic aspects
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