Pearly penile papules: absence of human papillomavirus DNA by the polymerase chain reaction

Article Abstract:

Genital human papillomavirus (HPV) infections are sexually transmitted infections that can cause genital warts, which are also known as condylomata acuminata. Infection with HPV has also been associated with an increased risk for genital tract cancers. Infected males usually have penile lesions, of which 30 percent will be condylomata acuminata. Controlling the spread of HPV has focused on identifying and treating infected males. Males with penile lesions resembling condylomata acuminata are usually diagnosed and treated as having HPV. Pearly penile papules are a type of penile lesion often confused with condylomata and thus men with them are often assumed to be infected with HPV. HPV treatment for these men has not been effective. This study examined if pearly penile papules contained HPV DNA, or genetic material specific to HPV. Tissue samples of pearly penile papules from 13 men were examined for HPV DNA using a test based upon the polymerase chain reaction. This technique amplifies the DNA enzymatically, making it easier to detect. Some of the men also had lesions resembling condylomata and these lesions were also tested. Results showed that no HPV DNA was detected in the tissue samples from the pearly penile papules. HPV DNA was detected in four of seven samples from lesions that were thought to be condylomata. These results indicate that the presence of pearly penile papules alone is not indicative of HPV infection. (Consumer Summary produced by Reliance Medical Information, Inc.)

Sexually transmitted diseases, Usage, Prevention, Papillomaviruses, Papillomavirus, Diseases, Polymerase chain reaction, Sexually transmitted disease prevention, Penis

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Diagnostic performance of Hybrid Capture human papillomavirus deoxyribonucleic acid assay combined with liquid-based cytologic study

Article Abstract:

The same sample used for a liquid-based Pap smear appears to be adequate to perform a genetic test to identify the human papillomavirus (HPV) thought to be a precursor to cervical cancer. The combination of these two tests seems to increase the accuracy in identifying cervical cancer than either test alone. A liquid-based Pap smear test, an HPV test, and a cervical tissue sampling test were performed on 364 women with previously abnormal Pap smears. Nearly all (95.1%) of the patients with advanced disease and most (87.7%) of the patients with early stage disease were identified with the combination tests.

Measurement, DNA, Cervix uteri, Cervix uteri biopsy

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