Peri-implantation phase endometrial estrogen and progesterone receptors: effect of ovulation induction with clomiphene citrate

Article Abstract:

After ovulation the two hormones estrogen and progesterone prepare the lining of the uterus for embryo implantation. Receptors on the surface of cells lining the uterus, the endometrium, have a particular affinity for progesterone and estrogen. It is thought that inadequate progesterone, estrogen or receptor activity is associated with the development an endometrium not conducive for implantation. Clomiphene citrate can be given to infertile women to stimulate ovulation by inhibiting the uptake of estrogen. However, the drug may also prevent implantation of embryos. The effect of clomiphene citrate on receptors for progesterone and estrogen was studied in 10 normally ovulating fertile women. Receptors for progesterone and estrogen were determined in one cycle during which women were given either 50 mg or 150 mg of clomiphene and one normal cycle without the drug. Clomiphene citrate did not affect receptors for progesterone or estrogen during the implantation phase of the menstrual cycle. (Consumer Summary produced by Reliance Medical Information, Inc.)

Hormone receptors, Ovum implantation

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E-cadherin and its messenger ribonucleic acid in periimplantation phase human endometrium in normal and clomiphene-treated cycles

Article Abstract:

E-cadherin is present in the endometrium around the time the egg is released and its presence is not affected by the drug clomiphene. E-cadherin is a protein in cell membranes that facilitates cell-to-cell contact. It may be important in the implantation of the fertilized egg. Researchers took biopsy samples of the inner lining of the uterus, or endometrium, several days after ovulation. During one menstrual cycle, the women took clomiphene and during the second cycle they took no drug. E-cadherin was present in endometrial samples even in the absence of clomiphene.

Measurement, Cell adhesion molecules

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Localization and expression of oxytocin receptor and its messenger ribonucleic acid in peri-implantation phase human endometrium during control and clomiphene-treated cycles

Article Abstract:

The hormone oxytocin and its receptor are found in the lining of the uterus during ovulation. This indicates that oxytocin may be involved in preparing the uterus for the fertilized egg. Oxytocin is also produced during labor.

Oxytocin, Ovulation

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