Paroxysmal Nocturnal Hemoglobinuria Cells in Patients with Bone Marrow Failure Syndromes

Article Abstract:

Paroxysmal nocturnal hemoglobinuria (PNH) is better diagnosed by flow cytometric analysis than by the Ham test, especially in patients with myelodysplasia, a condition of minor defects in the spinal cord. PNH is an acquired hematopoietic stem-cell disorder in which blood cells which are deficient in certain components appear intermittently in the urine, usually at night and usually for several days at a time. Of 115 patients with aplastic anemia, 22% showed signs of PNH. A similar percentage (23%) was found in patients with myelodysplasia. These results suggest that these patients might respond well to immunosuppressive therapy.

Diagnosis, Flow cytometry, Myelodysplastic syndromes

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Mechanisms of disease: Parvovirus B19

Article Abstract:

The symptoms and chances of the parvovirus B19 diseases are discussed. According to a study, the infection is common and probably occurs in childhood.

United States, Care and treatment, Development and progression, Pediatric diseases, Parvovirus infections

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