Pivampicillin versus doxycycline in the treatment of chlamydial urethritis in men
Article Abstract:
Nongonococcal urethritis is a sexually transmitted infection of the urethra, the tube leading from the bladder, caused by the bacteria chlamydia. Tetracycline or macrolide antibiotics are the treatment of choice. Although penicillin is not generally effective for treating nongonococcal urethritis in men, pivampicillin, an ampicillin derivative, laboratory studies have shown it to be effective. The efficacy of pivampicillin (700 mg twice a day for nine days) was compared with the tetracycline drug doxycycline (200 mg on day one followed by 100 mg for eight days) in 80 confirmed cases of chlamydial infections in men. Of the 40 men treated with pivampicillin, the treatment failed in five (12.5 percent), with three patients (7.5 percent) still testing positive for chlamydia. Of the 40 receiving doxycycline therapy, two patients (5.1 percent) had treatment failure, and one patient (2.6) still tested positive for chlamydia. There was no statistical difference between the two treatment groups. Although pivampicillin can be used effectively to treat nongonococcal urethritis in men, it is not considered the drug of choice. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1990
User Contributions:
Comment about this article or add new information about this topic:
Doxycycline and azithromycin for prevention of chlamydial persistence or recurrence one month after treatment in women: a use-effectiveness study in public health settings
Article Abstract:
The frequency of continued infection or reinfection appears to be similar in women treated with either a single or multiple dose of medication for chlamydia. Follow-up tests for chlamydia were performed on 196 infected women one month after either a single dose of azithromycin or multiple doses of doxycycline. Follow-up tests showed positive results in 5.1% of the patients taking azithromycin and 4.1% of the patients taking doxycycline. Those patients engaging in high-risk behaviors were two to three times more likely to have a treatment failure with either medication.
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
Double-Blind Comparison of Trovafloxacin and Doxycycline in the Treatment of Uncomplicated Chlamydial Urethritis and Cervicitis
Article Abstract:
The antibiotic trovafloxacin appears to be as effective as doxycycline in treating Chlamydia trachomatis infection in women but not in men. This was the conclusion of a study of 970 men and women with C. trachomatis infection who were randomly assigned to receive either drug.
Publication Name: Sexually Transmitted Diseases
Subject: Health
ISSN: 0148-5717
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: A controlled trial of cyclosporine in the treatment of primary biliary cirrhosis. Efficacy of liver transplantation in patients with primary biliary cirrhosis
- Abstracts: Leucopenia during sulphasalazine treatment for rheumatoid arthritis. Second line (disease modifying) treatment in rheumatoid arthritis: which drug for which patient?
- Abstracts: Decline in the risk of myocardial infarction among women who stop smoking. A case-control study of baldness in relation to myocardial infarction in men
- Abstracts: Risk factors for acute non-A, non-B hepatitis in the United States and association with hepatitis C virus infection
- Abstracts: Biomedical information, peer review, and conflict of interest as they influence public health. Editorial peer review in biomedical publication: the first international congress