Placental calcium transport during acute maternal hypermagnesemia in the rat

Article Abstract:

Hypermagnesemia in the maternal rat does not appear to affect the rate of calcium transfer across the placenta. In pregnant women, excessively high levels of magnesium in the blood appear to increase the infant's risk of rickets, which is a bone disease. Some have speculated that magnesium competes with calcium and blocks its transfer across the placenta. Five rats were injected with magnesium sulfate and five were injected with a salt solution. The average blood concentration of magnesium rose to 5.3 milligrams (mg) per deciliter (dl) in the rats that were injected with magnesium but remained at 1.8 mg/dl in the untreated rats. Even after treatment however, there was no difference in the rate of calcium transfer across the placenta between the groups. This suggests that rickets associated with hypermagnesemia is caused by magnesium's direct effect on bone and not by its interference with calcium transport.

Calcium in the body, Magnesium in the body, Magnesium (Nutrient)

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Dietary calcium and manganese effects on menstrual cycle symptoms

Article Abstract:

Increased levels of calcium and manganese in the diet may reduce menstrual cycle symptoms. Different menstrual cycle symptoms include pain, water retention and changes in mood, concentration and behavior. Ten women with a normal menstrual cycle were treated over four 39-day periods with 587 or 1,336 milligrams (mg) of calcium per day with 1.0 or 5.6 mg of manganese per day. The women had fewer menstrual cycle symptoms when they were fed a high-calcium diet. They experienced less pain and had fewer undesirable changes in behavior during menstruation. They also had less water retention during the premenstrual phase, the seven days preceding the onset of menstruation. Women had more pain and undesirable mood swings during the premenstrual phase when they were a fed a diet with low levels of manganese. These changes occurred regardless of the level of calcium in their diet.

Nutritional aspects, Menstruation disorders, Manganese in human nutrition, Manganese (Nutrient)

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Calcium carbonate and the premenstrual syndrome: effects on premenstrual and menstrual symptoms

Article Abstract:

Calcium supplements can substantially reduce symptoms in women with premenstrual syndrome. Researchers randomly assigned 466 women with premenstrual syndrome to take 1,200 milligrams of calcium per day or a placebo for three complete menstrual cycles. By the third cycle, the women taking calcium experienced a 48% reduction in symptom severity in the last two weeks of the menstrual cycle, compared to a 30% reduction in the women taking a placebo.

Diet therapy, Premenstrual syndrome

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