Prevalence and clinical relevance of 52-kDa and 60-kDa Ro/SS-A autoantibodies in Japanese patients with systemic sclerosis

Article Abstract:

The presence of the protein anti-Ro52 in patients with systemic sclerosis (SSc) may be a marker for Sjogren's syndrome. This syndrome, characterized by dry eyes and mouth, is an auto-immune disease previously associated with a complex of anti-Ro/SS-A antibodies. Blood samples taken from 27 patients with SSc that were positive for this complex were tested for the presence of the two component proteins, anti-Ro52 and anti-Ro60. Sjogren's syndrome was strongly associated with the presence of both proteins or with anti-Ro52 alone, but only one of the six patients with only anti-Ro60 had symptoms.

Health aspects, Autoantibodies, Sjogren's syndrome

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Antiubiquitin antibody in localised and systemic scleroderma

Article Abstract:

An antibody reactive to ubiquitin may play a role in localized scleroderma and systemic sclerosis. Ubiquitin is a common protein component of cell membranes. Localized scleroderma and systemic sclerosis are autoimmune diseases. Analysis of blood samples revealed positive antibody levels in 21 of 48 localized scleroderma patients and 22 of 52 systemic sclerosis patients. By comparison, levels were positive in 13 of 20 systemic lupus erythematosus patients, 2 of 20 dermatomyositis patients and none of 30 healthy volunteers.

Ubiquitin

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Serum concentrations of soluble P-selectin glycoprotein ligand-1 are increased in patients with systemic sclerosis: Association with lower frequency of pulmonary fibrosis

Article Abstract:

Systemic sclerosis is an autoimmune disorder due to antinuclear antibodies present. Serum concentrations of soluble P-selectin glycoprotein ligand-1 are used in patients with systemic sclerosis and the results are discussed.

United States, Science & research, Research, Glycoproteins, Pulmonary fibrosis, Sclerosis

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