Preventing IUCD-related pelvic infection: the efficacy of prophylactic doxycycline at insertion

Article Abstract:

Intrauterine contraceptive devices (IUD) have been associated with pelvic inflammatory disease (PID), bacterial infections in women affecting the reproductive organs. It is thought that PID develops when bacteria are introduced into the uterus during the process of IUD insertion. The effectiveness of preventative antibiotic therapy prior to IUD insertion was studied among 827 women receiving a single oral dose of 200 milligrams of doxycycline, and 828 placebo-treated women attending a family planning clinic in Kenya. Cultures were taken for two organisms responsible for PID infections, gonorrhea and chlamydia, before and after IUD insertion. The rate of PID in the doxycycline-treated group was 1.3 percent compared with 1.9 percent in the placebo-treated group, representing a 31 percent reduction in PID. The greatest reduction in IUD-related PID infections was seen for the bacterial infection caused by chlamydia. There were fewer unscheduled visits (31 percent) made to the health clinic specifically for IUD-related events among the doxycycline-treated women. Although the differences in PID between the two groups were not statistically significant, it is believed that the fewer unscheduled IUD-related visits indicates that doxycycline provides a protective effect against PID. (Consumer Summary produced by Reliance Medical Information, Inc.)

Health aspects, Prevention, Complications and side effects, Intrauterine contraceptives, Intrauterine devices, Pelvic inflammatory disease, Doxycycline

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Cefixime is ineffective in shigellosis in adults

Article Abstract:

Pivamdinocillin may be a better treatment for a Shigella bacterial infection in adults than cefixime. Doctors treated 30 adult males with diarrhea caused by a Shigella infection with either a daily 400 milligram (mg) dose of cefixime or four daily 400 mg doses of pivamdinocillin. Cefixime treatment was successful in only 8 of 15 patients while pivamdinocillin treatment was successful in all 15 patients. Patients treated with cefixime had more bloody stools for a longer period of time and their fever lasted significantly longer than those patients treated with pivamdinocillin. The Shigella bacteria were no longer present in 87% of the patients' stools after 2 days of pivamdinocillin treatment. This was the case in only 40% of the patients treated with cefixime.

Evaluation, Drug therapy, Antibacterial agents, Cefixime, Shigellosis, Bacillary dysentery

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