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Principle results of the Controlled Onset Verapamil Investigation of Cardiovascular End Points (CONVINCE) trial

Article Abstract:

Calcium channel blockers are not more effective than beta blockers or diuretics in reducing the risk of heart attack or stroke in patients with hypertension. This was the conclusion of a study of 16,602 patients, half of whom took a calcium channel blocker and half of whom took either a beta blocker or a diuretic. Most patients with hypertension should be treated with a diuretic and a beta blocker if necessary.

Author: Neaton, James D., Williams, Gordon, Lacourciere, Yves, White, William B., Weber, Michael A., Grimm, Richard H., Jr., Zanchetti, Alberto, Wittes, Janet, Elliott, William J., Black, Henry R., Grandits, Gregory, Grambsch, Patricia, Lucente, Tracy, Hansson, Lennart, Muller, James, Sleight, Peter, Anders, Robert J.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2003
Calcium Antagonists, Evaluation, Cooking, Calcium channel blockers, Verapamil, Cookery for hypertensives

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Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events

Article Abstract:

Dual antiplatelet therapy with clopidogrel plus low-dose aspirin was studied in a broad population of patients at high risk for atherothrombotic events. It was found that clopidogrel plus aspirin was not significantly more effective than aspirin alone in reducing the rate of myocardial infarction, stroke, or death from cardiovascular causes.

Author: Topol, Eric J., Haffner, Steven M., Cacoub, Patrice, Hankey, Graeme J., Bhatt, Deepak L., Berger, Peter B., Pearson, Thomas A., Montalescot, Gilles, Boden, William E., Creager, Mark A., Weber, Michael A., Hamm, Christian W., Black, Henry R., Flather, Marcus D., Fox, Keith A.A., Cohen, Eric A, Easton, J. Donald, Hacke, Werner, Johnston, Claiborne S., Koon-Hou Mak, Jean-Louis Mas, Steinhubl, Steven R., Brennan, Danielle M., Fabry-Ribaudo, Liz, Booth, Joan
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Aspirin, Aspirin Combinations, Comparative analysis, Atheroembolism, Plavix (Medication)

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Feasibility of treating prehypertension with an angiotensin-receptor blocker

Article Abstract:

A test was conducted to investigate whether pharmacologic treatment of prehypertension prevents or postpones stage 1 hypertension. Treatment of prehypertension with candesartan appeared to be well tolerated and reduced the risk of incident hypertension indicating that pharmacological treatment of hypertension is feasible.

Author: Weber, Michael A., Oparil, Suzanne, Egan, Brent M., Julius, Stevo, Messerli, Franz H., Black, Henry R., Michelson, Eric L., Nesbitt, Shawna, Schork, Anthony M., Kaciroti, Niko, Grimm, Richard H.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
Science & research, Research, Candesartan

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Subjects list: Hypertension, Drug therapy, Dosage and administration, New England
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