Prognostic significance of steroid receptors measured in primary metastatic and recurrent endometrial cancer

Article Abstract:

The survival of patients with endometrial cancer, cancer of the cells lining the inside of the uterus, can be estimated by factors such as the stage of the cancer, microscopic cell characteristics, depth of cancer invasion, and tumor grade. These factors are not useful in predicting the outcome of recurrent or advanced staged endometrial cancer. Progesterone and estrogen are hormones which have a particular affinity for receptors on the surfaces of certain cancer cells. The use of progesterone and estrogen receptor status to predict the survival of endometrial cancer patients was studied. The amount of progesterone and estrogen receptors were measured in 42 cases of recurrent endometrial cancer and 14 cases of advanced endometrial cancer. Of all the factors studied, the combination of progesterone receptor status, tumor grade, and site of cancer spread (metastasis) were the best predictors of survival. Positive progesterone and estrogen receptors and tumor grade indicated improved survival time. The measurement of progesterone and estrogen receptors may have prognostic value in predicting survival time in patients with advanced or recurrent endometrial cancer. (Consumer Summary produced by Reliance Medical Information, Inc.)

Prognosis, Cancer, Endometrial cancer, Cell receptors, Estrogen, Progesterone, Estrogen receptors, Progesterone receptors

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Blood flow characteristics of ovarian tumors: implications for ovarian cancer screening

Article Abstract:

Color flow Doppler ultrasound adds useful information to ultrasound imaging in attempting to determine whether ovarian tumors are benign or malignant. A group of 123 women with pelvic masses had ultrasound imaging done with a vaginal probe. They also had color flow Doppler ultrasound studies to analyze blood flow to and within the suspicious mass. Twenty-three of the tumors were eventually confirmed to be malignant, and 56 were confirmed as benign. Certain patterns of blood flow were more typical of benign tumors and certain other patterns were more typical of malignant tumors. However, color flow Doppler studies were not sufficient by themselves to distinguish between the two. Gray-scale imaging analysis and age and menopausal status of the patient taken together with Doppler flow analysis allowed better discrimination of which patients should undergo further investigation.

Usage, Blood flow, Diagnosis, Blood flow measurement, Doppler ultrasonography, Ovarian tumors

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Prevention of postoperative adhesions by an antibody to vascular permeability factor/vascular endothelial growth factor in a murine model

Article Abstract:

Postoperative adhesions may not develop as frequently or severely when vascular permeability factor (VPF) antiserum is administered during surgery. Researchers induced an abdominal injury by performing surgery on 28 mice and then administering either VPF antiserum or preimmune serum at the time of abdominal closure. Examination of mouse abdomens two weeks later revealed that mice that received VPF antiserum had fewer and less severe adhesions than mice that received preimmune serum. VPF promotes the formation of adhesions after surgery by causing blood vessels to leak. VPF antiserum should be given before, during, and for several days after surgery to prevent adhesion formation.

Prevention, Complications and side effects, Postoperative period, Adhesions

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