Proliferation and apoptosis of fibroblasts and smooth muscle cells in rat uterine cervix throughout gestation and the effect of the antiprogesterone onapristone

Article Abstract:

Cell death in cervical cells increases during late pregnancy and this process appears to be regulated by progesterone. The cervix must soften at the end of pregnancy to allow the baby to be delivered. Researchers studied the proliferation and cell death of collagen and smooth muscle cells in the cervixes of pregnant rats at various stages during the pregnancy. Cell proliferation was highest at the beginning of pregnancy and decreased, whereas cell death was lowest at the beginning of pregnancy and increased. Cell death was blocked by a chemical that inhibits progesterone.

Measurement, Cell death, Cell proliferation

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The promise and perils of microarray analysis

Article Abstract:

Microarray analysis has provided a novel means of identifying clues into the mechanisms of disease development and it can be used to differentially compare pathologically similar diseases tissues to predict response to chemotherapy and risk of recurrence. With proper confirmatory studies and cautious interpretation, microarray analysis has represented a powerful tool for molecular discovery.

In-Vitro Diagnostic Substance Manufacturing, Diagnostic substances, Reverse Transcriptase, Analysis, Polymerase chain reaction, Leiomyoma, DNA microarrays

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Further evidence of a decorin-collagen interaction in the disruption of cervical collagen fibers during rat gestation

Article Abstract:

A protein called decorin may be responsible for changing collagen in the cervix during labor. This is necessary so the cervix can stretch to let the baby pass through. A study in rats found that levels of decorin in the cervix increase as the pregnancy progresses.

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