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Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection

Article Abstract:

A combination of three IgG monoclonal antibodies against a chimeric simian-human form of HIV-1 protected pregnant macaque monkeys from infection. Their babies were also protected against infection for up to 6 months. This could be the basis of an effective mucosal AIDS vaccine.

Author: Baba, Timothy W., Liska, Vladimir, Hofmann-Lehmann, Regina, Vlasak, Josef, Xu, Weidong, Ayehunie, Seyoum, Cavacini, Lisa A., Posner, Marshall R., Katinger, Hermann, Stiegler, Gabriela, Bernacky, Bruce J., Rizvi, Tahir A., Schmidt, Russell, Hill, Lori R., Keeling, Michale E., Lu, Yichen, Wright, Joel E., Chou, Ting-Chao, Ruprecht, Ruth M.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
Models

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Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies

Article Abstract:

Anti-HIV-1 neutralizing monoclonal antibodies protected mice from a vaginal HIV challenge. This could be the basis of an effective AIDS vaccine, since HIV is usually transmitted via the mucosa.

Author: Katinger, Hermann, Stiegler, Gabriela, Mascola, John R., VanCott, Thomas C., Carpenter, Calvin B., Hanson, Chris E., Beary, Holly, Hayes, Deborah, Frankel, Sarah S., Birx, Deborah L., Lewis, Mark G.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
HIV (Viruses), HIV, Disease transmission

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Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies

Article Abstract:

The potency of three neutralizing antibodies in suppressing viral rebound in six acutely and eight chronically HIV-1-infected individuals undergoing interruption of antiretroviral treatment is evaluated to determine the protective potential of the humoral immune response against HIV-1. Only two of eight chronically infected individuals showed evidence of a delay in viral rebound during the passive immunization.

Author: Weber, Rainer, Katinger, Hermann, Stiegler, Gabriela, Fischer, Marek, Joos, Beda, Gunthard, Huldrych F., Oxenius, Annette, Huber, Michael, Trkola, Alexandra, Kuster, Herbert, Rusert, Peter, Leeman, Christine, Manrique, Amapola, Rehr, Manuela, Vcelar, Brigitta, Aceto, Leonardo
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
United States, Science & research, Care and treatment, Antiviral agents, Immune response, Antiretroviral agents

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Subjects list: Health aspects, Research, HIV infection, HIV infections, Monoclonal antibodies, AIDS vaccines
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