Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

Article Abstract:

Oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

HIV infection, HIV infections, Antiviral agents, Macaques

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Urgently needed: a filter for the HIV-1 vaccine pipeline

Article Abstract:

As a part of prophylactic vaccine to counter the spread of HIV-1, researchers are trying to make immunogens, which are intended to elicit the neutralizing antibody responses. The need for assay standardization and creation of a centralized testing facility that could distribute consensus protocols and reagents is discussed.

AIDS vaccines, Prophylaxis

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Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120

Article Abstract:

Research demonstrates that vaginal administration of the human monclonal antibody b12, produced against HIV-1 gp120 protein, protects macaque monkeys from simian-human immunodeficiency virus infection through the vagina. Data indicate that this protection is dose dependent with low doses being less effective.

United Kingdom, Usage, Infection, Communicable diseases, Disease transmission, Simian immunodeficiency virus, HIV antibodies

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