Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease

Article Abstract:

A multicenter, randomized, double-blind, placebo-controlled trial was conducted to determine whether the addition of intravenous methylprednisolone to conventional primary therapy for Kawasaki disease reduces the risk of coronary-artery abnormalities. The result data do not provide support for the addition of a single dose of pulsed intravenous methylprednisolone to conventional therapy in the routine primary treatment of Kawasaki disease.

Diagnosis, Corticosteroids, Kawasaki disease, Kawasaki syndrome, Corticosteroid drugs, Disease/Disorder overview

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Tolvaptan, a selective oral vasopressin [V.sub.2]-receptor antagonist, for hyponatremia

Article Abstract:

A study was conducted to investigate the effect of tolvaptan, an orally active vasopressin [V.sub.2]-receptor antagonist on predicting acute and chronic hyponatremia, which is used to predict death among patients with chronic heart failure and cirrhosis. The results show that tolvaptan, when added to standard therapy, despite consistent side effects, is of great help in raising and maintaining serum sodium concentrations in the patients.

Complications and side effects, Dosage and administration, Vasopressin, Vasopressins, Drug overview

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Hyponatremia among runners in the Boston marathon

Article Abstract:

A cohort of marathon runners is studied to estimate the incidence of hyponatremia and to identify the principal risk factors. Considerable weight gain while running, a long racing time, and body-mass-index extremes were associated with hyponatremia, whereas female sex, composition of fluids ingested, and use of nonsteroidal antiflammatory drugs were not.

United Kingdom, Usage, Nonsteroidal anti-inflammatory drugs, Nonsteroidal anti-inflammatory agents, Runners (Sports)

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