Regulation of the sodium pump in pregnancy-related tissues in preeclampsia

Article Abstract:

Women with preeclampsia may have fewer sodium pumps in their uterine tissue. The sodium pump is an enzyme in cell membranes that pumps sodium in and out of cells. Researchers analyzed samples of uterine tissue from 38 women, 27 of whom were pregnant and were having a cesarean section. Of these 27, 8 had preeclampsia, which is hypertension that occurs during pregnancy. The expression of two of the forms of sodium pump was much lower in the uterine samples from the women with preeclampsia. Reduction in the activity of the sodium pump could lead to increased muscle contraction, which could contribute to high blood pressure.

Physiological aspects, Preeclampsia, Adenosine triphosphatase, Myometrium

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Alterations in uterine sodium pump abundance may contribute to the onset and progression of term and preterm labor in mice

Article Abstract:

Sodium pump alpha3 (SPalpha3) protein abundance is determined at specific gestational time points by Western blot analysis in pregnant mice over the last one-third of pregnancy and in pregnancy mice that are in spontaneous active labor and 1 day after delivery. The results have shown that the SPalpha3-isoform protein levels decreased in uterus before term labor and lipopolysaccharide-induced preterm labor and the reduction in sodium pump number increased uterine contractile force and contributed to labor.

Science & research, All Other Basic Organic Chemical Manufacturing, Industrial organic chemicals, not elsewhere classified, Polysaccharides, Health aspects, Research, Risk factors, Premature labor, Pregnancy, Complications of, Pregnancy complications, Premature labour, Clinical report

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