Retrograded high-amylose corn starch reduces cholic acid excretion from the small bowel in ileostomy subjects

Article Abstract:

Most starch, a key source of energy in human diets, is absorbed easily by the small intestine, but resistant starch (RS) enters the colon intact and forms part of the substrate needed for bacterial fermentation. Previous studies suggest a strong inverse link between consumption of starch and incidence of bowel cancer. A new study investigates the effect of RS on bile acid and nutrient excretion from the small bowel in humans. The study of seven ileostomy patients shows a 42% reduction in cholic acid excretion from the small bowel by changing from ordinary corn starch to retrograded high-amylose corn starch. It is suggested that resistant starch could protect against colon cancer.

Research, Colorectal cancer, Starch, Diet therapy

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Sterol balance studies in man: a critical review

Article Abstract:

Methods of quantifying the metabolism of cholesterol in the body or the sterol balance technique is reviewed. Various studies employing the conventional sterol balance technique with or without excretion studies of labelled dietary cholesterol to see the effect of large amounts of cholesterol on protective body mechanisms have had conflicting results. The conflict may occur due to variable transit time in the small intestines and the possibility of bacterial degradation of cholesterol. The ileostomy model has also been used to study cholesterol metabolism. The sterol balance studies provide information for dietary advice in health and disease.

Physiological aspects, Blood cholesterol, Sterols, Cholesterol metabolism

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Olive oil instead of butter increases net cholesterol excretion from the small bowel

Article Abstract:

Eleven healthy ileostomates were studied to determine the effects of saturated fats (SAFA) against monounsaturated fats (MUFA) on small bowel sterol excretion by changing a controlled 100 gram fat diet from butter to olive oil. Bile acids and neutral sterols measured with gas chromatography showed that bile acid excretion was lower in the MUFA diet while sterol excretion was lower with SAFA. These findings suggest that the change from SAFA-rich to MUFA-rich diet exerts a cholesterol lowering effect.

Fatty acids, Cholesterol

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