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Risk factors for the development of preterm premature rupture of the membranes after arrest of preterm labor

Article Abstract:

Pregnant women whose preterm labor has been stopped with the use of drugs may be four times more likely to experience premature rupture of membranes and preterm delivery if they have indications of infection. Researchers studied 253 women with preterm labor for indications of infection in amniotic fluid. Forty-four women experienced premature rupture of membranes and had to deliver their infants before term. Women who experienced premature rupture of membranes were more likely to have positive indicators for amniotic fluid infection, be black, be less advanced in pregnancy, have partially dilated cervices at hospital admission, and have fewer contractions in the first hour of labor. Antibiotic treatment may not prevent premature rupture of membranes if infection is present.

Author: Romero, Roberto, Goldenberg, Robert L., Hauth, John C., Andrews, William W., Thom, Elizabeth, Guinn, Debra A.
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
Complications and side effects, Risk factors, Premature rupture of membranes, Premature rupture of the membrane, Premature labor

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The effect of low-dose aspirin on pregnancies complicated by elevated human chorionic gonadotropin levels

Article Abstract:

Pregnant women with high levels of human chorionic gonadotropin (HCG) may benefit from receiving treatments of low doses of aspirin. Elevated levels of HCG may be associated with pregnancy complications such as preterm delivery, low birth weight infants, and preeclampsia. Researchers compared the effects of low-dose aspirin on 262 healthy pregnant women to the outcomes of 420 healthy pregnant women who did not receive aspirin. Women who took aspirin gave birth to infants with significantly greater birth weights than did women who did not take aspirin. This increase may have been due in part to the slightly longer pregnancies of women who took aspirin. Aspirin may reduce the effect of damaged blood vessels in the placenta by preventing vessel constriction.

Author: Goldenberg, Robert L., Hauth, John C., Wenstrom, Katharine D., DuBard, Mary B., Lea, Colleen
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1995
Physiological aspects, Aspirin, Chorionic gonadotropin, Chorionic gonadotropins

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Elevated amniotic fluid interleukin-6 levels at genetic amniocentesis predict subsequent pregnancy loss

Article Abstract:

Some pregnancy losses following amniocentesis may be due to silent intrauterine infections present before the procedure. Researchers measured interleukin-6 levels in amniotic fluid samples taken from 66 women who miscarried a normal fetus after amniocentesis and compared values with 66 women with healthy pregnancies matched for year of test, gestational age, maternal age, and indication for amniocentesis. Interleukin-6 mediates inflammatory processes and is a marker for infection. Eight of the 66 women who miscarried had extremely high values compared with the rest of the women.

Author: Andrews, William W., Tamura, Tsunenobu, Johnston, Kelley E., Wenstrom, Katharine D., DuBard, Mary B., Hemstreet, G. Philamon
Publisher: Elsevier B.V.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
Analysis, Infection, Measurement, Causes of, Uterus, Miscarriage, Amniotic fluid, Interleukin-6

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