Severe isoniazid-associated hepatitis - New York, 1991-1993

Article Abstract:

Ten patients in New York developed severe hepatitis after treatment with isoniazid (INH). INH is a drug used to prevent or treat tuberculosis (TB). All of the patients were evaluated for a liver transplant at transplant centers in New York and Pennsylvania between Jan 1991 and May 1993. Of the eight patients who received long-term treatment with INH alone, five received a liver transplant and three died while waiting for a transplant. One patient died after liver transplantation. None of the eight patients had used alcohol heavily, but three had taken other drugs associated with drug-induced hepatitis. No evidence of infection with hepatitis A or B was found in any of the patients. Patients treated with INH should have monthly checkups. They should also be informed about the signs and symptoms of drug-induced hepatitis.

Isoniazid

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Update: Fatal and Severe Liver Injuries Associated With Rifampin and Pyrazinamide for Latent Tuberculosis Infection, and Revisions in American Thoracic Society/CDC Recommendations--United States, 2001

Article Abstract:

Doctors should closely monitor liver function in patients with latent tuberculosis infection who are treated with two months of rifampin and pyrazinamide. Between February and August, 2001, 21 patients taking these drugs developed liver damage. Patients at risk of liver damage can be treated with nine months of isoniazid instead.

Drug therapy, Liver, Tuberculosis

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Fatal and Severe Hepatitis Associated With Rifampin and Pyrazinamide for the Treatment of Latent Tuberculosis Infection--New York and Georgia, 2000

Article Abstract:

Some patients may develop hepatitis from two drugs that are used to treat tuberculosis. Two months of rifampin and pyrazinamide are sometimes used instead of a nine-month treatment with isoniazid. Patients who receive the two-month treatment should have their liver function monitored on a regular basis.

Antitubercular agents

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