Signal transduction using nitric oxide and cyclic guanosine monophosphate

Article Abstract:

A winner of the 1996 Lasker awards describes his research on nitric oxide and cyclic guanosine monophosphate (GMP). He studied cyclic GMP as a second messenger, which is a chemical whose synthesis is stimulated by a hormone. Focusing on the enzyme that produces cyclic GMP, he found that many nitrogen compounds could activate the enzyme. The most likely component that could account for this was nitric oxide. Nitric oxide has been shown to be involved in many processes, including smooth muscle relaxation, platelet aggregation and neurotransmission.

Muscle relaxants

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The discovery of endothelium-derived relaxing factor and its importance in the identification of nitric oxide

Article Abstract:

A winner of the 1996 Lasker awards describes his research that led to the discovery of endothelium-derived relaxing factor. He used strips of rabbit aorta to test different drugs and chemicals that affect blood vessels. In one experiment, acetylcholine unexpectedly caused the strips to relax rather than contract. A substance was isolated from the endothelial cells in the strip and named endothelium-derived relaxing factor, or EDRF. There is much evidence that EDRF is nitric oxide or a very similar chemical.

Endothelium-derived relaxing factors

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Nitric Oxide Deficiency as a Cause of Clinical Hypertension: Promising New Drug Targets for Refractory Hypertension

Article Abstract:

Drugs that boost the production of nitric oxide may be beneficial in treating hypertension. Nitric oxide relaxes blood vessels so if it is deficient, blood vessels will constrict, thereby raising blood pressure.

Hypertension, Causes of

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