Smoking, smoking cessation, and major depression

Article Abstract:

A group of individuals drawn from three different areas of St. Louis, Missouri were involved in a survey to examine the relationship between depression and cigarette smoking. The epidemiological catchment areas that were used included urban, suburban and rural areas, so that the subject profiles would be similar to those in the general national population. Results from 3,213 subjects were included in this report. The Diagnostic Interview Schedule was used to collect demographic information and cigarette use history, and contained sections designed to investigate whether the subject had ever suffered major depressive disorders. An association between the rate of cigarette smoking and the presence of symptoms indicative of a major depressive illness was found. Some data suggest that when certain individuals who have a history of major depressive disorder stop smoking, serious depression may follow. The increase in rate of smoking of depressed individuals may also help explain why groups of individuals with major depressive illnesses have a high mortality. While smoking was related to major depression, a similar relationship was not found between smoking and other forms of psychiatric illness. (Consumer Summary produced by Reliance Medical Information, Inc.)

Psychological aspects, Surveys, Depression, Mental, Depression (Mood disorder), Smoking, Tobacco habit

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Publication Bias and Research on Passive Smoking

Article Abstract:

Studies with non-significant results may be less likely to be published or may be delayed compared to those with significant results. Researchers contacted 65 scientists who had submitted a total of 61 articles on passive smoking to a scientific journal between 1981 and 1995. Some were animal studies and some were conducted on humans. It took 4-7 years for articles with non-significant results to be published, compared to 3-5 years for those with significant results. Fourteen of the articles had not been published.

Publishing industry, Research, Medical research, Passive smoking, Manuscripts

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Efficacy of sertraline in the treatment of children and adolescents with major depressive disorder: two randomized controlled trials

Article Abstract:

The antidepressant drug sertraline may be effective in treating severe depression in children and teenagers, according to a study of 376 children and teenagers in the US, India, Canada, Costa Rica, and Mexico. Sixty-nine percent had lower scores on a test used to diagnose depression after 10 weeks of treatment. However, 59% of the children who took a placebo, or inactive substance, also had lower scores after 10 weeks. Sertraline belongs to a group of drugs called SSRIs.

Evaluation, Drug therapy, Sertraline, Depression in children, Childhood depression

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