Specific immunotherapy: one size does not fit all

Article Abstract:

Altered peptide ligands, which are modified peptide determinants and recognized by T-cells of the immune system, may prove useful for the treatment of cancer, immunodeficiencies, and asthma. This article discusses the ongoing investigations that employ altered peptide ligands as therapeutic agents in the treatment of multiple sclerosis.

Canada, Research, Analysis, Peptides, T cell antigen receptors, T cells, Immune response, Immunotherapy

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Glutamate excitotoxicity in a model of multiple sclerosis

Article Abstract:

Research presented examines the role of glutamate excitotoxicity in multiple sclerosis-related oligodendrocyte and axon damage. Findings suggest a link between glutamate excitotoxicity and autoimmune demyelination, and AMPA/kainate antagonists may prove to be a possible therapy for preventing demyelination.

Glutamate

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Autoimmune encephalomyelitis ameliorated by AMPA antagonists

Article Abstract:

Research presented concerns the physiological aspects of multiple sclerosis and autoimmune encephalomyelitis, focusing on the degeneration of myelin and neurons which are the hallmarks of these diseases. Researchers note the possible role of AMPA antagonists in multiple sclerosis therapy.

Encephalomyelitis, Demyelination

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