Specific interaction of CD4-bearing liposomes with HIV-infected cells

Article Abstract:

The human immunodeficiency virus (HIV) binds to and enters into cells by way of a molecule known as CD4. This experiment showed that lipid (fatty acid) molecules known as liposomes, which contain CD4, bind to HIV-infected cells but not to uninfected cells. The HIV-infected cells had been grown outside the body in tissue culture. The contents of the liposome is then brought inside of the cell. This provides a possible way for direct delivery of antiviral agents to HIV-infected cells, by placing the drugs inside of the liposomes. CD4+ liposomes also bind to free units of HIV, that are not attached to cells. Further study is needed to determine whether CD4+ liposomes can bind to infected cells or to the virus inside of a living person, since these findings were achieved in tissue culture in the laboratory. (Consumer Summary produced by Reliance Medical Information, Inc.)

Research, Usage, Drug therapy, Liposomes, Artificial cells

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Life span of circulating membrane CD4 inserted into the plasma membranes of autologous red blood cells of HIV-infected subjects

Article Abstract:

Red blood cells with electroinserted recombinant CD4 T cells circulated for at least 28 days without immune response or side effects in four HIV-infected patients. This is an improvement over the time period for soluble CD4. Blood measurements were unchanged by insertion of rCD4. One of the subjects showed a large increase of CD4 cells, but with a corresponding decline in CD8 cells. CD4 apparently needs a membrane for a longer life span in order to prevent the virus from moving around and attaching to cells that produce HIV. This could prove to be a valuable therapeutic approach in the treatment of AIDS.

Care and treatment, CD4 lymphocytes

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Selection of appropriate HIV-1 genomic regions for single-strand conformation polymorphism analysis of the diversity, modification, and transmission of HIV-1 quasispecies

Article Abstract:

The p2 region of the genetic code for HIV may show a high degree of variability, which may be associated with HIV transmission. Researchers used single-strand conformation polymorphism analysis of HIV in 114 infected plasma samples, including samples from HIV-infected mothers and their infant children. The V1, V2, V3, and p2 gene regions of the viral genetic code seemed to be particularly relevant to the development of viral genetic variation and disease transmission. The subtype of HIV infecting the mothers most commonly was the type which infected their children.

Genetic aspects, Disease transmission, Genetic polymorphisms

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