Statement on use of apolipoprotein E testing for Alzheimer disease

Article Abstract:

The apolipoprotein E genotype (APOE) seems to be a risk factor for Alzheimer disease, however, genotyping is not recommended as a diagnostic test for the disease. The predictive value of APOE testing is questionable because Alzheimer disease often develops in people who do not have the APOE genotype. Even if the APOE genotype is present, as many as 50% of those with the genotype to not develop Alzheimer's disease. It is possible that other factors such as cholesterol level and a low-density lipoprotein receptor gene may modulate the influence of the genotype on Alzheimer's development,but this has not been proven. APOE testing may prove to be helpful in evaluating treatment options for patients.

Evaluation

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Alzheimer disease research comes of age: the pace accelerates

Article Abstract:

Research on Alzheimer's disease (AD) continues at an increasing pace. Although scientists do not know exactly how AD develops or how to prevent it, research is shedding light on some of the factors involved. Mutations in several genes have been linked to AD, but widespread genetic screening has not yet been recommended. The presence of cerebrovascular disease appears to increase the severity of AD. An algorithm has been developed to predict which patients will require nursing home admission. Many cases of mild dementia go unrecognized by family members.

Editorial, Ethical aspects

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Evidence for an Alzheimer Disease Susceptibility Locus on Chromosome 12 and for Further Locus Heterogeneity

Article Abstract:

There appears to be a gene associated with Alzheimer's disease on chromosome 12. This was the conclusion of a group of researchers who used genetic analysis to find such a link in 53 families with a history of Alzheimer's disease. Although the precise location of the gene could not be determined, a region on the chromosome was identified. Genes conferring susceptibility to Alzheimer disease have also been found on chromosomes 1, 14, 19, and 21.

Research, Gene mutations, Gene mutation

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