bcl-2 protein in non-small-cell lung carcinoma

Article Abstract:

The five-year survival rate may be higher for non-small-cell lung cancer patients with abnormal production of bcl-2 protein. Bcl-2 protein is the product of the bcl-2 proto-oncogene. The bcl-2 proto-oncogene may be involved in the regulation of cell death rather than cell division. Among 122 patients who had surgery for non-small-cell lung cancer, 80 had squamous-cell carcinoma and 42 had adenocarcinoma. Abnormal production of bcl-2 protein was found in 25% of the patients with squamous-cell carcinoma and 12% of those with adenocarcinoma. Patients with bcl-2 protein were likely to survive five years after diagnosis than those without. Patients over 60 years old with bcl-2 protein had the highest chance of survival.

Physiological aspects, Development and progression, Oncogenes, Lung cancer, Non-small cell, Non-small cell lung cancer

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Sorafenib in advanced clear-cell renal-cell carcinoma

Article Abstract:

A phase 3, randomized, double-blind, placebo-controlled trial of sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis in patients with advanced clear-cell renal-cell carcinoma was conducted. Results revealed that oral sorafenib therapy prolonged progression-free survival in patients with advanced clear-cell renal-cell carcinoma in whom first-line therapy had failed.

Drug therapy, Dosage and administration, Carcinoma, Renal cell, Renal cell carcinoma, Drug overview, Sorafenib

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