Stressed out obesity and insulin resistance

Article Abstract:

Various tests and studies are conducted to show that the chronic activation of the proinflammatory pathway in insulin target tissues leads to insulin resistance and hence obesity in people suffering from the type 2 diabetes. The results prove that the activation of the endoplasmic reticulum (ER) stress pathway in addition to the metabolic stress in the liver and muscles and the free fatty acids released from obese adipose tissues plays a very important role in this phenomenon.

California, Diagnosis, Risk factors, Type 2 diabetes, Insulin resistance

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Obesity: autonomic circuits versus feeding

Article Abstract:

Dysfunction of autonomic neural circuits rather than feeding behavior may be of great importance in obesity. Central nervous system regulation of eating and autonomic outflow are not always parallel in energy homeostasis. The autonomic nervous system is important in regulating insulin production be pancreatic beta cells, too. This is important in the development of obesity, but the relationship is complex. Leptin receptor expression is discussed.

United States, Research, Abnormalities, Leptin, Nervous system, Autonomic, Autonomic nervous system

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Spotting a killer's target in autoimmnue diabetes

Article Abstract:

Researchers have identified the B chain of insulin as the target of CD8 lymphocytes in a mouse model of diabetes. Type 1 diabetes is caused by an autoimmune attack on islet beta cells in the pancreas, which eventually destroys them.

Identification and classification, Type 1 diabetes, Autoantigens

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