Suppression of experimental autoimmune encephalomyelitis by selective blockade of encephalitogenic T-cell infiltration of the central nervous system

Article Abstract:

Results show that blockade of the receptor for advanced glycation end products (RAGE) suppresses experimental autoimmune encephalomyelitis, during myelin basic protein or peptide or encephalitogenic T cells induced disease. Data indicate that the RAGE inhibition significantly reduceses central nervous sysem infiltration by immune and inflammatory cells.

United States, China, Physiological aspects, Autoimmune diseases, Multiple sclerosis, T cells, Encephalomyelitis, Disease susceptibility

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RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

Article Abstract:

The upshot of amyloid-beta cells transport across the blood-brain-barrier is illustrated. The development of cerebral amyloidosis has targeted the vascular rage for inhibiting pathogenic consequences of A-beta-vascular interactions.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Medical Research, Epilepsy & Muscle Disease R&D, Administration of Public Health Programs, Health Research Programs, Amyloidosis, Cell transplantation, Medicine, Experimental, Blood-brain barrier, Cerebral amyloid angiopathy

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