Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV

Article Abstract:

A prospective, randomized, multicenter noninferiority study comparing the regiments of tenofovir DF, emtricitabine and efavirenz and a fixed dose of zidovudine and lamivudine plus efavirenz were conducted. Results revealed that the combination of tenofovir DF and emtricitabine plus efavirenz fulfilled the criteria for noninferiority to a fixed dose of zidovudine and lamivudine plus efavirenz and proved superior in terms of virologic suppression, CD4 response, and adverse events resulting in discontinuation of the study drugs.

New England States, Clinical trials, HIV infection, Drug therapy, HIV infections, New England, Lamivudine, Efavirenz (Medication)

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Efficacy and safety of tenofovir DF vs. stavudine in combination therapy in antiretroviral-naive patients

Article Abstract:

Tenofovir disoproxil fumarate (DF) is the first nucleotide analog reverse transcriptase inhibitor approved for treatment of human immunodeficiency virus (HIV) and a test was conducted to assess its efficacy and safety compared with stavudine in antiretroviral-naive patients. It was found, over a period 144 weeks, that combination of tenofovir DF, lamivudine and efavirenz was highly effective and also comparable with a combination of stavudine, lamivudine and efavirenz in antiretroviral-naive patients.

Care and treatment, HIV (Viruses), HIV

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Efficacy and safety of Emtricitabine vs. Stavudine in combination therapy in antiretroviral-naive patients

Article Abstract:

A test was conducted to assess the efficacy and safety of emtricitabine as compared to stavudine in combination with didanosine and efavirenz. It was found that drug, emtricitabine administered once daily showed greater virological efficacy, steady response and tolerability as compared to stavudine administered twice daily combined with didanosine and efavirenz.

Usage, Evaluation, Antiviral agents, Anti-HIV agents, Highly active antiretroviral therapy

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