The advantages of using triple-marker screening for chromosomal abnormalities

Article Abstract:

An analysis of the mother's blood may help pregnant women aged 35 or over decide whether to have an amniocentesis. Pregnant women aged 35 or over who refused amniocentesis were offered a screening test for genetic defects. A group of 10,605 samples were drawn between 15 and 22 weeks gestation and analyzed for alpha-fetoprotein, human chorionic gonadotropin, and unconjugated estriol. Of this group, 880 women, or 8.3%, tested positive. After errors in due date were corrected, 766 women were offered amniocentesis of whom 704 accepted. Outcomes were known for 93% of the screen-positive women and for 73% of the overall population. Sixteen cases of Down's syndrome were detected of the 19.5 cases that would have been expected based on maternal age, for a detection rate of 63%. Thirteen other pregnancies with chromosomal abnormalities were detected.

Methods, Genetic screening, Genetic testing, Prenatal diagnosis

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The urinary bladder of a woman is a novel site of luteinizing hormone-human chorionic gonadotropin receptor gene expression

Article Abstract:

Luteinizing hormone-human chorionic gonadotropin receptors have been found to be present in the urinary bladder of a woman. The results suggest that bladder functions in women may be regulated by luteinizing hormone-human chorionic gonadotropin. Bladder trigone and the female reproductive tract have a common embryologic origin in the intermediate mesoderm along the urogenital ridge.

Women, Hormone receptors, Luteinizing hormone, Bladder

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Maternal serum alpha-fetoprotein and human chorionic gonadotropin levels in women with human immunodeficiency virus

Article Abstract:

Pregnant women who have HIV infection may have higher blood levels of human chorionic gonadotropin and alpha-fetoprotein than other pregnant women, according to a study of 98 pregnant women. This is important to know because these two substances are part of a prenatal blood test for Down syndrome.

HIV infection, HIV infections

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