The autoimmune diseases
Article Abstract:
Autoimmune diseases occur when the body produces antibodies against its own tissue. Systemic lupus erythematosus is characterized by the production of antibodies against the cell nucleus (antinuclear antibodies, or ANA) and the deposition of antibodies, complement and immune complexes in various tissues. Rheumatoid arthritis involves the production of ANAs, as well as rheumatoid factor. Deposition of antibodies in the joint can cause a localized inflammatory reaction. Juvenile rheumatoid arthritis occurs in children and adolescents and is similar to adult rheumatoid arthritis. Sjogren's syndrome is caused by the production of antibodies to tear ducts, salivary glands and other glands. Scleroderma (systemic sclerosis) also involves the production of antibodies against the cell nucleus and nucleolus. Polymyositis is characterized by an infiltration of muscle tissue by lymphocytes, which results in inflammation.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1992
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Neurology
Article Abstract:
Studies of tissue plasminogen activator in the treatment of stroke reveal that the risks of bleeding may outweigh any benefits the drug provides. This may be true for other thrombolytic drugs, which break up the blood clots that cause most strokes. Genetic mutations have been found in patients with amyotrophic lateral sclerosis and Parkinson's disease. A new form of Creutzfeldt-Jakob disease in humans may be related to mad cow disease. Research suggests that multiple sclerosis may be an immune disorder and a vaccine is being tested. Herpes simplex virus may also be involved.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1997
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